In vitro fertilization (IVF) is a popular and effective treatment option for couples struggling with infertility. However, despite its success rate, many couples who undergo IVF treatment experience multiple failures before achieving a pregnancy. This can be a difficult and emotional journey for couples, as they may experience feelings of disappointment and frustration.

In this article, we will discuss some of the common reasons behind multiple IVF failures and what can be done to improve the chances of success.

Causes of multiple IVF failure

  1. Egg abnormalities

One of the most common reasons for multiple IVF failures is poor egg quality. As women age, the quality of their eggs decreases, making it more difficult to achieve a pregnancy. Additionally, certain medical conditions, such as polycystic ovary syndrome (PCOS), can also affect egg quality. Women with PCOS may have a higher number of immature eggs, which can make it difficult to achieve a successful pregnancy. To improve egg quality, couples may need to consider using donor eggs or pursuing other fertility treatments.

  1. Wrong Embryo Selection

 Embryos are formed from fertilized eggs, and their quality can be affected by a variety of factors, including the quality of the sperm and eggs used, as well as the overall health of the parents. Factors such as genetic disorders, chromosomal abnormalities, and poor sperm motility can all affect the quality of the embryos. To improve embryo quality, couples may need to consider using assisted reproductive technologies, such as ICSI, or sperm or egg donor.

  1. Uterine Issues

The irregular shape of the uterus, fibroids, polyps, scarring, tough cervix and intrauterine adhesions are among structural uterine issues that can contribute to implantation failure. Another major uterine concern is a thin endometrium caused by an early surge in progesterone prior to egg extraction in an IVF cycle.

  1. Immune System Issues 

Some women have an immune system that recognizes the embryo as foreign and attacks it, causing implantation failure. This can be treated with medications that suppress the immune system, such as prednisone and intravenous immunoglobulin (IVIG).

  1. Age Factor

As a woman gets older, her fertility begins to decline. The chances of success with IVF decrease as a woman ages. This is because the number and quality of her eggs decrease with age. Additionally, the uterus may not be as receptive to implantation as it was in the past. Women over the age of 35 may have a harder time getting pregnant, and the success rates of IVF decrease as a woman gets older.

  1. Lifestyle Factors

Lifestyle factors can also play a role in multiple IVF failures. Being overweight or underweight, regular smoking, alcohol consumption, and certain medications can negatively affect fertility. Stress can also play a role in infertility, as it can affect the menstrual cycle and ovulation. To improve the chances of success with IVF, couples should focus on improving their overall health and well-being. This may include losing weight, quitting smoking, and reducing stress levels.


In conclusion, multiple IVF failures can be caused by a variety of factors, including poor egg quality, endometriosis, age, and lifestyle factors. To improve the chances of success with IVF, couples should consider using donor eggs or sperm. Couples can pursue other fertility treatments, or focus on improving their overall health and well-being. 

It’s also important to consult with a fertility specialist who can determine the underlying cause of infertility and recommend the most appropriate course of treatment. It’s important for couples to understand that IVF is not always successful and it’s not uncommon to experience multiple failures before achieving a pregnancy. But with the right approach and the right team, it’s possible to overcome these challenges and achieve a successful pregnancy.

Consider Ferticare services by scheduling a free consultation to know more about the prospects of getting pregnant. We provide support for surrogacy, donor sperm, egg IVF, IUI, and natural pregnancy. We offer individualised treatment that is appropriate for your requirements and circumstances.

Visit our website right now at www.ferticare.in to locate the fertility treatment that will work best for you.

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